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KMID : 0363220080460081145
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Korean Journal of Dermatology
2008 Volume.46 No. 8 p.1145 ~ p.1148
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A Case of Lichenoid Drug Eruption with Whole Body and Oral Mucosal Involvement Caused by Antituberculosis Drugs
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Na Chan-Ho
Chung Byoung-Soo
Shin Bong-Seok
Seo Hyun-Deok
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Abstract
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Lichenoid drug eruption can arise as a result of exogenous compound exoposures and closely mimic idiopathic lichen planus. A 45-year-old man who had taken antituberculosis drugs (isoniazid, rifampin, ethambutol, pyrazinamide) for 2 months developed pruritic violaceous papules and plaques with silvery scales on the whole body. On close inspection, he had superficial erosions on the lips and reticulate white papules on the buccal mucosa. Histopathologic findings were hyperkeratosis, parakeratosis, and hypergranulosis in the epidermis and band-like lymphohistiocytic infiltration, numerous eosinophils, and perivascular lymphohistiocytic infiltration in the dermis. The skin lesions improved leaving hyperpigmentation after cessation of the antituberculosis drugs and application of topical corticosteroid.
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KEYWORD
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Antituberculosis drugs, Lichenoid drug eruption
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